منابع مشابه
Micromanaging a large tumor suppressor
Two parallel and concordant activities characterize cell cycle progression. One is associated with preparation for and execution of DNA replication followed by mitosis (" cell cycle "). Cyclins are the motors of the cell cycle, as they activate the respective CDKs and thereby drive the cell through the sequential phases of the cycle. Their antagonists are CKis, which inhibit the CDKs stalling t...
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Granular cell tumor is a rare benign neoplasm most commonly appears in the head and neck region, especially in the tongue, cheek mucosa, and palate. Occurrence in limbs is even rarer. These tumors account for approximately 0.5% of all soft tissue tumors. Granular cell tumor can also affect other organs including skin, breast, and lungs. Local recurrence and metastasis is potentially higher in m...
متن کاملMicromanaging senescence
Normal somatic cells have a limited capacity for division in culture and eventually enter a state of terminal growth arrest termed replicative senescence [1]. Cells that fail to undergo senescence divide indefinitely and develop chromosomal aberrations resulting in neoplastic transformation. Senescence is believed to be a tumor suppressor mechanism that ensures that cells permanently exit the c...
متن کاملEvidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations.
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The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2012
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.22935